NAA and Celiac Disease
Natural autoantibodies (NAA) are closely related to the pathogenesis and treatment of celiac disease. Creative Biolabs is a leading provider of NAA testing and analysis services and NAA Detection Kits. We have a team of experienced professionals and an advanced technology platform to provide a full range of NAA services for celiac disease research.
Description of Celiac Disease
Celiac disease is an immune-mediated bowel disorder caused by the ingestion of gluten in genetically susceptible individuals. The major susceptibility genes are located on chromosome 6 of the HLA system, namely HLA-DQ2 and DQ8 genes, which are present in at least 95% of patients. It is characterized by the presence of chronic inflammation of the small bowel's mucosa and submucosa and is clinically characterized by the presence of diverse systemic manifestations. The current diagnosis is based on intestinal disease as revealed by a biopsy of the small intestine, where histological examination revealed villous atrophy, crypt hyperplasia, and intraepithelial lymphocytosis, as well as circulating CeD specific antibodies against tissue transglutaminase (tTG), deaminated gliadin peptide (DGP), and endomysium (EMA).
Celiac Disease Develop Pathway
Gluten in food is degraded into peptides by gastrointestinal enzymes and then transferred to the lamina propria through the epithelial barrier. In celiac disease individuals, some of these peptides can bind to HLA-DQ2 or HLA-DQ8 heterodimers expressed on the surface of antigen-presenting cells and, after triggering T-cell responses, lead to local tissue damage. Gluten-activated T cells release pro-inflammatory cytokines, which induce mucosal inflammation and have a direct cytotoxic effect on the epithelium, all of which finally lead to villous atrophy in the small intestine. In addition, specific T cells induce B cells to produce antibodies against DGP and TTG2. Thus, this adaptive (specific) T-cell response is necessary for the development of celiac disease. Nevertheless, innate immunity also plays an important role in the development of celiac disease. Although gluten is the main external cause of celiac disease, gluten intake does not fully explain the pathogenesis of the celiac disease.
Fig.1 Key steps in celiac disease pathogenesis.1
NAA Services for Celiac Disease at Creative Biolabs
- NAA Services for Anti-Transglutaminase 2 Antibodies (ATG2A)
- NAA Services for Anti-Transglutaminase 3 (TG3) Antibodies
- NAA Services for Anti-Factor XIII Antibodies
- NAA Services for Anti-actin Antibodies
- NAA Services for Anti-calreticulin Antibodies
- NAA Services for Anti-gangliosides Antibodies
- NAA Services for Anti-collagens Antibodies
- NAA Services for Anti-synapsin I Antibodies
- NAA Services for Anti-zonulin Antibodies
- NAA Services for Anti-cardiolipin Antibody
- NAA Services for Anti-ATP Synthase β Chain
- NAA Services for Anti-Enolase α
Celiac Disease Related Products at Creative Biolabs
The production of autoantibodies is an important feature of many autoimmune diseases, marking the destruction of immune tolerance to autoantigens. In celiac disease, an autoimmune enteropathy with multiple extra-intestinal manifestations, autoantibody reactivity to transglutaminase 2 (TG2) has been shown to closely correlate with the acute phase of the disease. It is a specific and sensitive marker of celiac disease and is very useful in aiding diagnosis and follow-up
| Target | Product Name | Cat. No. |
|---|---|---|
| Thyroid peroxidase (TPO) autoantibody | Human Thyroid peroxidase (TPO) Autoantibody (IgG) ELISA kit | NAK-064 |
| GAD autoantibody | Mouse GAD Autoantibody (IgG) ELISA Kit | NAK-001 |
| AMA-M2 autoantibody | Human AMA-M2 Autoantibody (IgG) ELISA kit | NAK-013 |
| single-stranded DNA autoantibody | Human single-stranded DNA Autoantibody (IgG) ELISA kit | NAK-062 |
| Extractable nuclear antigens (ENA) autoantibody | Human Extractable nuclear antigens (ENA) Autoantibody (IgG) ELISA kit | NAK-038 |
| Cardiolipin, Phosphatidyl Serine, Phosphatidyl Inositol and Phosphatidic acid autoantibody | Human Cardiolipin, Phosphatidyl Serine, Phosphatidyl Inositol and Phosphatidic acid Autoantibody (IgG&IgM ) ELISA kit | NAK-053 |
Celiac disease is a multifactorial intestinal disorder. Although villous atrophy and crypt hyperplasia in small intestinal biopsy specimens remains the gold standard for diagnosis, celiac disease-specific antibodies are widely used as diagnostic aids. At Creative Biolabs, we are highly experienced in NAA analysis. We have the expertise to optimize each stage of NAA projects to ensure you get your desired outcome, achieving the highest levels of efficiency throughout. If you are interested in our NAA services and products, please contact us for more information.
Reference
- Tye-Din, Jason A., Heather J. Galipeau, and Daniel Agardh. "Celiac disease: a review of current concepts in pathogenesis, prevention, and novel therapies." Frontiers in pediatrics 6 (2018): 350.